Immunohistochemical profile of canalicular adenoma of the. They have a predilection for upper lip but can be found throughout the oropharynx. A case of canalicular adenoma arising on the upper lip. It is necessary to histopathologically differentiate canalicular adenoma from basal cell adenoma.
A rare presentation of canalicular adenoma of the parotid gland. However, during an electronmicroscopic examination of a canalicular adenoma, the ultrastructural features were found to be quite different from those of socalled basal cell adenomas of the 1s 0 parotid gland. We report 12 cases of canalicular adenoma that arose in the palates of nine women and three men between the ages of 42 and 76 years. Canalicular adenoma wikimili, the free encyclopedia. Basal cell adenoma bca and canalicular adenoma ca are rare salivary gland tumors.
Canalicular adenomas are a rare form of benign tumour that occur in salivary glands, occurring mainly in the upper lip and minor salivary glands of the buccal mucosa. Histologically, trabecular type of basal cell adenoma, pleomorphic adenoma and polymorphous lowgrade adenocarcinoma should be discriminated from canalicular adenomas. Cells of the canalicular adenoma showed an immunohistochemical profile that indicates an excretory duct origin. Article information, pdf download for basaloid monomorphic adenomas open. Canalicular adenomas represent 1% of all salivary gland neoplasms and 4% of minor salivary gland neoplasms. Rarely, it manifests itself clinically and histologically as a multifocal lesion, a feature not generally seen with other intraoral salivary gland tumors. Pleomorphic adenomas are the most common benign tumors of salivary glands and occur mainly in the parotid gland. To simplify one can say that canalicular adenoma and basal cell adenoma being more common due to the presence of a uniform type of cells can be categorized as a few of the subtypes of monomorphic adenoma 1.
Original article canalicular adenoma of the minor salivary. As observed in several other sgts, a commonly encountered finding is the presence of prominent cystic morphology. In addition, 6 cases of pa were reclassified to myoepithelioma. Monomorphic adenoma canalicular type nelson 1973 cancer. Given the usual small biopsies, ihc may be useful in distinguishing canad from other tumors in the differential diagnosis. Miller, dds, msd canalicular adenoma is composed of a row of tall columnar cells adjacent to canalicular lumina and a row of conical cells adjacent to connective tissue stroma. Introduction the canalicular adenoma is an uncommon, benign salivary gland tumor that most frequently occurs in the upper lip and very rarely in other sites like. This is a very rare benign neoplasm, that makes up about 1% of all salivary gland tumors, or about 4% of all benign salivary gland tumors. Canalicular adenoma of the parotid gland the journal of. Canalicular adenoma ca is an uncommon benign neoplasm of the minor salivary glands, accounting for approximately 1% of all salivary gland. An 80yearold female presented with nine submucosal nodules of the upper labial mucosa and bilateral buccal mucosa. Age and sex distribution it is estimated that canalicular adenomas of salivary gland constitute about 6% of all benign salivary gland tumors. Canalicular adenoma cad is an uncommon benign salivary gland tumor. Differential diagnosis of the canalicular adenoma versus adenocarcinoma is important, as it may result in unjustified radiotherapy or extensiv.
The authors report the fifth case and the first in the otorhinolaryngological literature of a canalicular adenoma of the parotid gland. The canalicular adenoma is an uncommon, benign salivary gland tumor that most frequently occurs in the upper lip and very rarely in. Nov 17, 2019 canalicular adenoma is a benign, epithelial salivary gland neoplasm arranged in interconnecting cords of columnar cells. Given the usual small biopsies, ihc may be useful in distinguishing canad from other tumors in the differential diagnos. Rarely, this benign tumor may occur multifocally in the oral cavity. Nly a few cases of canalicular adenoma have been previously reported. Canalicular adenoma is one of the more common adenomas, but as with all salivary gland tumours, there is a wide variation from institute to institute, from country to country, etc. Bcl2, salivary gland neoplasms, apoptosis, pleomorphic adenoma, adenoid cystic carcinoma, mu coepidermoid carcinoma. It differs from basal cell adenoma, of the parotid by. The upper lip is the most common location, accounting for over 80% of all cases.
Wikiproject dentistry rated startclass, lowimportance this article is supported by wikiproject dentistry. Canalicular adenoma ca is a benign salivary gland tumor sgt almost exclusively affecting the minor salivary glands, predominantly of the upper lip, and exhibiting characteristic histopathologic features. Dec 01, 1994 canalicular adenoma is a newly recognized salivary gland adenoma that may be confused with malignant salivary gland tumors. Canalicular definition of canalicular by the free dictionary. Histopathologic examination revealed multifocal circumscribed tumor islands with a tubular growth pattern within a loose hypocellular myxoid background. Canalicular adenoma is an uncommon benign neoplasm of the salivary glands. Synchronous multifocal canalicular adenomas springerlink.
Canalicular adenoma is an uncommon salivary neoplasm affecting almost exclusively the minor salivary glands, and representing % of all salivary tumors nelson and jacoway, 1973, batsakis, 1991, furuse et al. Canalicular adenoma of the parotid gland hilaris publishing srl. Canalicular adenoma arising from the nasal septum in a child. Database was mounted and analyzed using the stataic. Large recent studies from three different countries the uk, the usa and china reported a wide range and canalicular adenoma represented 012 % of all benign tumours. Canalicular adenomas are uncommon, benign epithelial neoplasms of the salivary glands that usually involve the upper lip and buccal mucosa of elderly people. They present as wellcircumscribed, firm, movable, slowgrowing, painless nodules. Canalicular adenoma is a benign neoplasm of the salivary glands. Canalicular adenomas published in english in the scientific literature in the last ten years 20062016. Canalicular adenoma is a rare benign tumor of the minor salivary glands that is the most prevalent in older adults mean age, 60 years. Bilateral canalicular adenomas of the upper lip request pdf.
Canalicular adenoma of the upper lip an electron microscopic study sowyeh chen, bmd,phd, and arthur s. Canalicular area fluorescencetotal couplet fluorescence. A high proportion of canalicular adenomas occur in the upper lip, a predilection not evident in other salivary gland tumours 4. The upper lip is the most commonly affected site, followed by the buccal mucosa and palate. Canalicular adenoma ca is an uncommon benign salivary gland tumor that mostly occurs in the upper lip. The term canalicular adenoma was first coined by mcfarland in 1942. Multiple canalicular adenomas arising in the buccal mucosa. It is most common in the 7th decade of life but can occur from 4th to 9th decades of life. Clinical and histological features of multifocal canalicular. Canalicular adenoma of the lacrimal gland iovs arvo journals.
Despite this predilection for the upper lip, there are reports of canalicular adenomas occurring in the lower lip. Canalicular adenoma is a rare benign salivary gland tumor that occurs almost exclusively in the upper lip. Accepted for publication 11 april 2005 introduction case reports canalicular adenoma is an uncommon, benign saliv case 1. A rare presentation of canalicular adenoma of the parotid. Clinically, it usually presents as an asymptomatic nodule on the upper lip or buccal mucosa. Canalicular adenoma is a rare benign tumor arising almost exclusively within. Mar 02, 2021 canalicular adenoma is a benign neoplasm of a salivary glands which originally was considered to be a variant of basal cell adenoma. The upper lip is the most common location, accounting for over 80% of all cases, followed by the buccal mucosa.
They occur in the upper lip mucosa in about 90% of cases, and the majority arise in patients over 50 years of age4,6,8,9,12,14. Canalicular adenoma is a benign, epithelial salivary gland neoplasm arranged in interconnecting cords of columnar cells. Keywords canalicular adenoma 4 lip 4 buccal 4 palate 4. Nov 01, 2020 the use of the terms monomorphic adenoma, basal cell adenoma, and canalicular adenoma as applied to salivary gland tumors oral surg oral med oral pathol, 56 1983, pp. If you continue browsing the site, you agree to the use of cookies on this website.
Canalicular adenoma a case report of a rare benign tumor. Clinical, morphological and immunohistochemical findings. Canalicular adenoma is a benign neoplasm of a salivary glands which originally was considered to be a variant of basal cell adenoma. Nov 01, 1984 the canalicular adenoma is an uncommon, benign salivary gland neoplasm that usually occurs in or near the upper lip of elderly patients. The clinical features were studied in a series of previously unreported salivary gland tumors 5 canalicular adenomas and 8 basal cell adenomas and 99 examples derived from the literature 68 canalicular adenomas and 31 basal cell adenomas. Canalicular adenoma is a benign salivary gland neoplasm. It has a greater tendency to involve the minor salivary glands.
Canalicular adenoma is a rare benign tumor that arises in the minor salivary gland. Dmd3bb slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Canalicular adenoma is a benign neoplasm that is almost exclusively of minor salivary gland origin. On this basis adenoma sebaceum pringle and senile sebaceous adenoma are generally no longer considered adenomas. Histopathologic examination revealed multifocal circumscribed tumor islands with a tubular growth pattern within a loose hypocellular myxoid. Immunohistochemical analysis of salivary gland canalicular. It appears as a slowgrowing node, less than 3 cm in diameter, painless.
The canalicular adenoma is an uncommon, benign salivary gland neoplasm that. Canalicular adenomas are rare benign tumours of the salivary glands, almost exclusively found in the upper lips and have a multifocal tendency. Canalicular adenoma salivary gland, histopathology youtube. A rare case report and revie of literature j clin case rep. To better characterize this neoplasm, six examples were investigated with a panel of immunohistochemistry antibodies including antikeratin ae1 ae3, antiepithelial membrane antigen, anticarcinoembryonic antigen, antivimentin, antis100, antimuscle specific actin. For the immunohistochemical reactions by the polymeric biotin free technique. If you want to participate andor join, please visit the project page, or ask questions on the project talk page. Canalicular adenoma is an unusual benign epithelial neoplasm of the minor salivary glands located primarily on the upper lip. Other locations include the buccal mucosa, the palate, and the parotid gland. Canalicular adenomas cas are uncommon benign salivary gland neoplasms of the oral cavity. It usually appears as a firm and mobile slowgrowing mass. The histological features of canalicular adenomas are similar to, but can be distinguished from, the trabe.
The canalicular adenoma is an uncommon, benign salivary gland neoplasm that usually occurs in or near the upper lip of elderly patients. To our knowledge, canalicular adenoma arising in the esophagus has never been described in the english literature. The upper lip is the most commonly affected site, followed by the buccal mucosa and. A histologic study of 49 tumors revealed that they are often multifocal, may infiltrate their capsule, and are occasionally unencapsulated. The canalicular adenoma is an uncommon, benign salivary gland tumor that most frequently occurs in the upper lip and very rarely in other sites like parotid. Clinical, morphological and immunohistochemical findings in. A56 year old female patient with asymptomatic intramandibular canalicular adenoma was presented. Distinct monomorphic adenoma with bilayered strands or ribbons of columnar cells with pure luminal ductal epithelial differentiation and loose, well vascularized stroma oral surg oral med oral pathol 1983. Incidence and profile of benign epithelial tumors of salivary. Immunohistochemical expression of bcl2 in benign and malignant. Canalicular adenoma does not commonly occur in the palate. The canalicular adenoma is an uncommon benign salivary tumor with distinct histological characteristics and a proclivity for the upper lip, followed by the buccal mucosa and palate and rarely the parotid gland.
Multifocal canalicular adenoma of the minor labial. Basal cell adenoma of the salivary glands is an uncommon type of monomorphous adenoma. They occur in females over the age of 50 and are usually single nodules. The upper lip is the site most often involved for ca, whereas bca. Canalicular adenoma ca is an uncommon, benign salivary gland. Canalicular adenomas from five patients were examined by light and electron microscopy. It occurs almost exclusively in the upper lips, next common site being the buccal mucosa. Occurrences in the parotid gland and other major salivary glands are described, but rarely. Canalicular adenoma salivary gland, histology, pathologyvia pathpresenterfollow me on twitter.
With the exception of the canalicular adenoma, the basaloid monomorphic. Ca has a significant predilection for occurrence in the minor. Canalicular adenomas are benign neoplasms that arise from salivary glands and often present as painless enlarging nodules. Canalicular adenoma accounts for 1% of all salivary gland tumors. Canalicular adenoma ca is a benign neoplasm that can manifest from minor salivary gland ductal tissue throughout the oral cavity and infrequently in the parotid gland. Canalicular adenomas are uncommon benign salivary gland neoplasms, which derive from the minor salivary glands. Canalicular adenoma cad is an uncommon benign tumor of minor salivary glands with predilection for the upper labial mucosa. Canalicular adenoma arising in the esophagus archives of. The most common site of occurrence is the upper lip.
Canalicular adenoma canad is an uncommon benign salivary gland neoplasm. The term canalicular adenoma was first coined by mcfarland2 in 1942, and. The basal cell adenoma was once considered to be a type of monomorphic adenoma. Oct 01, 2017 canalicular adenoma is an uncommon salivary neoplasm affecting almost exclusively the minor salivary glands, and representing % of all salivary tumors nelson and jacoway, 1973, batsakis, 1991, furuse et al. Within oral cavity upper lip is the most common site for this tumor followed by buccal mucosa and sometimes it. The canalicular adenoma is an uncommon, benign salivary gland tumor that most frequently occurs in the upper lip. Canalicular adenoma is the second most common type of adenoma of the oral region and arises almost exclusively in the upper lip. Canalicular adenoma ca is a benign neoplasia of salivary glands, which although representing less than 1% of salivary gland tumours, is the second or third most common benign tumour of minor.
Their incidence peaks during the seventh decade of life. It presents as a nodular lesion without a tendency for recurrence. Pdf cytological features of intraoral tumour jacks jorge. Whether or not true adenoma of sebaceous glands exists is still an unsettled question. There is a lack of a comprehensive immunohistochemical ihc analysis of canalicular adenoma canad, especially when combined with a description of the unique histologic features. In the past, there was difficulty differentiating benign salivary gland tumors because the classification schemes failed to separate canalicular adenoma from other. Authors of recent articles are almost unanimously in agreement that adenoma sebaceum pringle represents an organic nevus. Bilateral canalicular adenoma of the parotid gland. Canalicular adenoma of a minor salivary gland on the.
Other locations arebuccal mucosa, the palate and the parotid gland. Histologically, isomorphic cells in nests and interlaced trabecules with a prominent basal membrane are observed. Feb 01, 1984 the evidence that canalicular adenomas and basal cell adenomas are separate entities is presented in this article. Fine needle aspiration introduction canalicular adenoma ca is an uncommon, benign salivary gland tumor that was described by the world health organization classification in 1991 1. Dec 08, 20 canalicular adenoma panopio, kathleen cay m. It occurs in the upper lip mucosa in about 90% of cases, and a majority arise in patients over 50 years. Abstract the canalicular type of monomorphic adenoma is a rare salivary gland tumor that has had infrequent notice in the literature. Kleinsasser and klein were the first to designate the term basal cell adenoma and to establish it as a distinct clinical and pathologic entity in 1967. Mar 01, 2005 canalicular adenomas are benign neoplasms with a unique predilection for the upper lip 80% of cases.
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